Platelet monoamine oxidase B activity in parkinsonian patients.

نویسندگان

  • U Bonuccelli
  • P Piccini
  • P Del Dotto
  • G M Pacifici
  • G U Corsini
  • A Muratorio
چکیده

Monoamine oxidase B (MAO B) plays a pivotal role in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced Parkinsonism. An increased MAO B activity in platelets of patients with idiopathic Parkinson's disease (PD) is reported in this study. The possibility that high MAO B activity may represent a trait of vulnerability for PD by enhancing the neurotoxic effects of environmental compounds is discussed.

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Platelet monoamine oxidase B and plasma beta-phenylethylamine in Parkinson's disease.

OBJECTIVE To evaluate the correlation between changes in platelet monoamine oxidase type B (MAO-B) activity and plasma beta-phenylethylamine (PEA) concentrations in patients with Parkinson's disease and controls. METHODS Platelet MAO-B activity and plasma PEA were measured with gas chromatography-mass spectrometry (GC-MS) in patients with Parkinson's disease treated with levodopa (12 men and ...

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Platelet monoamine oxidase B and plasma â-phenylethylamine in Parkinson’s disease

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Central catecholamine metabolism in vivo and the cognitive and motor deficits in Parkinson's disease.

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عنوان ژورنال:
  • Journal of neurology, neurosurgery, and psychiatry

دوره 53 10  شماره 

صفحات  -

تاریخ انتشار 1990